ozempic dosing for weight loss ( Semaglutide )

ozempic dosing for weight loss ( Semaglutide )

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ozempic dosing for weight loss ( Semaglutide )

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Description

Ozempic Dosing For Weight Loss

What Is Ozempic?

Ozempic dosing for weight loss is a prescription medication used to treat and manage Type 2 Diabetes. Semaglutide, the active ingredient in Ozempic dosing, mimics the action of one of your body’s natural hormones (GLP1).

ozempic dosing also responsible for making you feel full and as a result, reducing your appetite. GLP1/Semaglutide also delays the emptying of your stomach which again goes toward making you feel fuller for longer.

In clinical studies, Ozempic / Semaglutide has been shown to be effective and acceptable for use by patients with Type 2 Diabetes. The clinical evidence also suggests that Semaglutide may also help obese patients with weight loss, leaving the patient feeling more satisfied after eating.

This suggests that Semaglutide may be a more potent drug and possibly better suited to those with a higher BMI or who may be classed as obese. The license indication is for type 2 diabetes and studies have looked at weight loss as a secondary endpoint. Recently, clinical trials focusing on weight loss as a primary endpoint completed and now, the regulatory authorities are reviewing them for a license to treat weight loss and obesity. Prescribing Ozempic for weight loss in the UK is therefore off-license, although clinically justified.

It’s important to note that this medication holds a license for type-2 diabetes treatment, but does not have a license for weight loss treatment. Prescribing for weight loss is therefore off-label.

If you have any concerns or queries – get in touch with us and one of our experts will be happy to help.

Weight Loss and Ozempic.

Whilst they have marketed and licensed Ozempic for Diabetes, the active ingredient (Semaglutide) has shown to suppress appetite and help the person taking it feel fuller quicker after a meal and for longer. This means that those taking Semaglutide are not just likely to consume less during a meal, feeling fuller for longer would mean being less likely to snack as much between meals. Patients may also start eating smaller portions than they’re used to due to this reduction in appetite. An overall significantly less calorie deficit would tend to result in patients beginning to lose weight when they start taking Ozempic.

How Effective is Semaglutide (Ozempic) for Weight Loss?

Researchers have carried out a number of clinical trials to demonstrate the effectiveness of Semaglutide as a weight loss drug. In one such study, 957 participants had taken part, all with a BMI of 30 or above, over 18 years of age and non-diabetic. The study found that 957 participants with a BMI of 30 kg/m2 or more took part in a clinical trial to test the efficacy of Semaglutide as weight loss drug. Eligible participants were adults over the age of 18 years, who did not have diabetes. 37-65% of those taking Semaglutide lost an estimated 10% or more body weight across all doses. In comparison, only 10% of the participants who took the placebo (non-active medication) experienced the same weight loss.

This study concluded that when combined with dietary and physical activity counselling, patients tolerated semaglutide well over 52 weeks and it demonstrated clinically relevant weight loss compared to placebo at all doses.

The UK already offers Semaglutide for prescription under the name of Ozempic®, licensed to treat type-2 diabetes. We have submitted an application to the regulatory authorities for approval as a weight loss medication in the near future.

The USA has approved Ozempic, and sufficient clinical evidence supports its use in weight loss. People who do not have Type 2 Diabetes have generally well-tolerated it with no new safety concerns arising in recent clinical trials. An independent prescriber can prescribe it for weight loss, provided they deem it clinically appropriate and justified.

How To Get Ozempic, and How Is Ozempic Taken?

Ozempic is a once weekly pre-filled injectable pen. Attached the single-use needle which comes in the box, dial the dose to the required level and inject into the stomach or thigh. Each pen lasts 4 weeks.

The beginning dose is 0.25 mg once a week for the first 4 weeks. This will allow your body to acclimate to the medicine. At Week 5, you will increase the dose to 0.5 mg once a week, followed by 1.0mg. Once you have reached 1.0mg you remain on that for the duration of your treatment.

You can watch the video on how to use the Ozempic pen by clicking here.

You can download and read the patient information leaflets (PIL) for each dose of Ozempic from the provided link.

Side effects

New medication requires the body to adjust and may cause side effects. Some of the most common side effects are the following:

  •  Feeling sick (nausea)
  •  Diarrhoea
  •  Constipation
  •  Indigestion
  •  Inflamed stomach (gastritis)
  •  Reflux or heartburn)
  •  Stomach pain and bloating of the stomach
  •  Burping
  •  Gallstones
  •  Tiredness
  •  Increase of pancreatic enzymes (such as lipase and amylase).

These do tend to go away over time once your body has adjusted to it.

Do ensure that you have read the patient information leaflet to be fully aware of the all the side effects.

Additional information

Doses

0.25mg, 0.1mg, 1.0mg

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